Cardiovascular
Weighted markers include ApoB, LDL-C, blood pressure, and resting heart rate. These have strong links to atherosclerotic and vascular risk over time.
LifeIndex methodology
LifeIndex is a longitudinal scoring framework that synthesizes selected bloodwork and wearable signals into one healthspan score on a 500-900 scale.
What the score measures
Metabolic
Weighted markers include HbA1c, fasting glucose, and selected body composition context where available. These reflect insulin dynamics and metabolic strain.
Recovery
Wearable recovery signals include resting heart rate trend, HRV trend, and sleep consistency proxies where available in standardized export fields.
Activity
Wearable activity signals include training volume and consistency proxies from recent periods to capture movement behavior and conditioning exposure.
Why these domains
Cardiovascular, metabolic, recovery, and activity domains capture most modifiable, behavior-linked longevity risk signals available in routine practice.
This structure aligns with practical preventive medicine models and enables a single framework that clinicians and patients can revisit every retest cycle.
Selected references:
- Levine et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018.
- Mandsager et al. Cardiorespiratory fitness and long-term mortality. JAMA Netw Open. 2018.
- Peter Attia. Outlive framework discussion on major chronic disease drivers.
How the score is calculated
The score range is 500-900, not 0-100, to avoid false precision at the extremes and to mirror realistic human variation in a health-data-rich population.
Domain scores are normalized and combined using a weighted average. Weights are set by signal reliability and expected longitudinal value in current model scope.
500High-risk signal concentration across multiple domains.
650Mixed profile with meaningful improvement headroom.
750Strong profile, often top-quartile relative to age peers.
850Consistently strong domain performance over time.
900Exceptional signal profile; uncommon in general populations.
What the score does not measure
LifeIndex does not currently include every clinically relevant signal, and it does not diagnose disease states or predict specific events.
The score should not be used as a standalone medical decision engine. It is a structured measurement layer to support longitudinal interpretation.
Longitudinal design
Trajectory is prioritized over snapshot. A score that moves from 700 to 730 in six months is often more clinically meaningful than a static high score with no progress.
Peer percentile is provided for context, but the primary use case is change within the same individual across time windows.
Data inputs required
- Recent bloodwork with core lipid and glycemic markers.
- Recent wearable summary with recovery and activity fields.
- Basic demographic context for age-cohort comparisons.
Missing inputs reduce confidence and can suppress domain resolution. The model still returns a score when minimum viable fields are present.
Future model development
Next versions will expand supported biomarkers, refine weights using larger cohorts, and improve handling for sparse or irregular data coverage.
We are evaluating additional signals now, but only promote them once they meet repeatability and interpretability standards.
Explore the clinic partnership track